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. 2017 Mar 21;19:32. doi: 10.1186/s13058-017-0824-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Selection of the informative list of 3472 gene signatures. a Distribution of the number of genes per signature and overall number of signatures from each sources of signatures. b Distribution of the proportion of patients assigned to the low, independent and high classes by the region of independence (ROI)₉₅ computed for all signatures and obtained after random permutation of gene labels over the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset. c Percentage of informative signatures for each of the different sources