Table 4.

Results of mRNA expression in tracheal epithelial cells after CBNP exposure

	P90		P90-BaP		P90-9NA		AS-PAH
	10 μg/ml	30 μg/ml	10 μg/ml	30 μg/ml	10 μg/ml	30 μg/ml	10 μg/ml	30 μg/ml
KC	1.1 ± 0.2	1.1 ± 0.2	1.2 ± 0.2	0.7 ± 0.2	1.3 ± 0.2	1.2 ± 0.3	3.8 ± 1.5*	2.4 ± 0.6*
IL-6	0.7 ± 0.2	0.8 ± 0.1	1.0 ± 0.2	0.6 ± 0.1*	1.3 ± 0.3	0.7 ± 0.1*	2.0 ± 0.8	2.6 ± 0.4*
Gpx3	2.2 ± 0.9	0.7 ± 0.1*	0.8 ± 0.2	0.8 ± 0.1	1.7 ± 0.7	0.7 ± 0.1	5.2 ± 3.8	1.3 ± 0.5
Gr	0.7 ± 0.1*	0.7 ± 0.1*	1.0 ± 0.1	1.0 ± 0.1	1.4 ± 0.2	1.0 ± 0.2	1.5 ± 0.3	1.7 ± 0.5
Cyp1a1	1.4 ± 0.4	0.8 ± 0.3	331 ± 22*	1289 ± 412*	2.0 ± 1.0	30 ± 9*	1157 ± 232*	2442 ± 452*
Cyp1b1	0.2 ± 0.1*	0.2 ± 0.0*	5.3 ± 1.0*	10.9 ± 2.4*	1.3 ± 0.1	2.5 ± 0.6*	11.1 ± 4.3*	4.3 ± 0.7*

Data show the n-fold mRNA expression after CBNP exposure compared to medium controls. Exposure time was 24 h. Data are mean ± SEM. n = 5–7, *p < 0.05 CBNP compared to medium controls analyzed by Wilcoxon signed-rank test

Gpx3 Glutathione peroxidase 3, Gr Glutathione reductase, KC keratinocyte chemoattractant, IL-6 interleukine-6, Cyp1a1/Cyp1b1 Cytochrome P450 subtypes 1a1 and 1b1