Table 1.
Clinicopathological characteristics of patients with primary invasive breast cancer and ovarian metastases
| Clinicopathological characteristics | N = 46 | % |
|---|---|---|
| Age at diagnosis of breast cancer, years - median (range) | 36.5 (28–40) | - |
| BRCA gene mutation | ||
| No | 8 | 17.4 |
| Yes, BRCA 1 | 1 | 2.2 |
| Yes, BRCA 2 | 0 | 0.0 |
| Unknown | 37 | 80.4 |
| Breast tumor localization | ||
| Left | 23 | 50.0 |
| Right | 21 | 45.7 |
| Both | 2 | 4.3 |
| Most extensively performed breast surgery | ||
| Needle biopsy | 4 | 8.7 |
| Breast conserving surgery | 15 | 32.6 |
| Mastectomy | 27 | 58.7 |
| Breast tumor histological subtype | ||
| Ductal | 36 | 78.2 |
| Lobular | 5 | 10.9 |
| Ductolobular | 5 | 10.9 |
| Scarff-Bloom-Richardson grade | ||
| I | 4 | 8.7 |
| II | 19 | 41.3 |
| III | 15 | 32.6 |
| Unknown | 8 | 17.4 |
| Estrogen receptor | ||
| Negative | 5 | 10.9 |
| Positive | 41 | 89.1 |
| Progesterone receptor | ||
| Negative | 8 | 17.4 |
| Positive | 38 | 82.6 |
| Her2/neu receptor | ||
| Negative | 38 | 82.6 |
| Positive | 8 | 17.4 |
| Tumor stage | ||
| T1 | 11 | 23.9 |
| T2 | 24 | 52.2 |
| T3 | 7 | 15.2 |
| T4 | 4 | 8.7 |
| Nodal stage | ||
| N0 | 14 | 30.4 |
| N1 | 12 | 26.1 |
| N2 | 10 | 21.7 |
| N3 | 10 | 21.7 |
| Distant metastasis | ||
| cM0 | 39 | 84.8 |
| cM1 | 7 | 15.2 |
| Age at diagnosis of ovarian metastases, years - median (range) | 40.0 (31–51) | - |
| Time between breast cancer and ovarian metastases, months - median (range) | 41.9 (0.3–141.8) | - |
| Recurrent disease prior to oophorectomy | ||
| No | 15 | 32.6 |
| Yes, locoregional recurrence | 12 | 26.1 |
| Yes, distant recurrence | 19 | 41.3 |
| Type of ovarian surgery | ||
| Unilateral oophorectomy | 0 | 0.0 |
| Bilateral oophorectomy | 46 | 100.0 |
| Indication for oophorectomy | ||
| Prophylactic because of breast cancer | 9 | 19.6 |
| Therapeutic because of breast cancer | 25 | 54.3 |
| Abnormal ovaries on ultrasound | 12 | 26.1 |
| Localization of ovarian metastases | ||
| Left | 4 | 8.7 |
| Right | 6 | 13.0 |
| Both | 29 | 63.0 |
| Unknown | 7 | 15.2 |