Table 3.
Immunohistochemical expression of the investigated markers in invasive breast tumors and their corresponding ovarian metastases
| Marker | % of positive tumor cells in invasive ductal carcinoma | % of positive tumor cells in invasive lobular carcinoma | % of positive tumor cells in invasive ductolobular carcinoma | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Breast tumors (n = 44) | Ovarian metastases (n = 58) | Breast tumors (n = 7) | Ovarian metastases (n = 10) | Breast tumors (n = 7) | Ovarian metastases (n = 7) | |||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| E-cadherin | 91 | 18 | 91 | 20 | 9 | 23 | 0 | 0 | 73 | 35 | 51 | 41 |
| EMA | 86 | 23 | 84 | 24 | 86 | 32 | 64 | 32 | 97 | 6 | 99 | 2 |
| Her2/neu | 76 | 35 | 81 | 31 | 88 | 26 | 74 | 26 | 80 | 34 | 67 | 38 |
| CEA | 56 | 40 | 57 | 39 | 73 | 32 | 59 | 26 | 62 | 32 | 56 | 33 |
| αvβ6 integrin | 51 | 40 | 45 | 39 | 54 | 35 | 38 | 28 | 45 | 30 | 29 | 35 |
| EpCAM | 36 | 42 | 38 | 39 | 38 | 46 | 68 | 26 | 19 | 29 | 35 | 29 |
| SD = standard deviation | ||||||||||||
The mean percentages of immunohistochemically positive stained tumor cells are subdivided by histological subtype. Tumor cell membranes were considered positive if they showed immunoreactivity of any intensity. EMA, epithelial membrane antigen; Her2/neu, human epidermal growth receptor type 2; CEA, carcinoembryonic antigen; EpCAM, epithelial cell adhesion molecule