Table 3.
GSEA of DNVs in High-5HT and Normal-5HT groups with network modules implicated in ASD (italics: p < 0.05)
MAGI1 (80) | MAGI2 (24) | MAGI3 (91) | DAWN1 (19) | DAWN2 (20) | DAWN3 (58) | DAWN4 (113) | |
---|---|---|---|---|---|---|---|
LoFs (16) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 3 (8.921e−05) |
Mis-Ds2 (56) | 1 (0.199) | 0 (1.000) | 0 (1.000) | 1 (0.051) | 0 (1.000) | 2 (0.011) | 0 (1.000) |
High-5HT_LoFs (5) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) |
High-5HT_Mis-D2(10) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) |
Normal-5HT_LoFs (8) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 0 (1.000) | 3 (9.216e−06) |
Normal-5HT_Mis-D2 (38) | 1 (0.140) | 0 (1.000) | 0 (1.000) | 1 (0.035) | 0 (1.000) | 2 (5.280e−03) | 0 (1.000) |