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Nrf2 activation is required for arsenic-induced p62 expression: (A) Immunoblot analysis of p62, Nrf2, and GAPDH in HaCaT cells transfected with siRNA targeting negative control (siCon) or Nrf2 (siNrf2). The cells were treated with or without arsenic (8 μM) for 6 h; (B–E) Real-time PCR analysis of the mRNA levels of: NQO1 (B); GCLC (C); HO-1 (D); and p62 (E) in cells as in (A). * p < 0.05, Student’s t-test, statistically significant between comparison groups.
