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SMase activity of β-toxin induces platelet aggregation through integrin activation. (A) Representative aggregation curves showing treatment of platelets with wild-type β-toxin or H162A, D163A, and H289N mutants. H162A and H165A mutants induce robust aggregation response. However, treatment with the H289N mutant does not induce aggregation. (B) Pretreatment with EGTA inhibits the aggregation response invoked by wild-type β-toxin or the D163A mutant.
