Table 2.
Biological pathways significantly enriched in the functional interaction networks related to 76 genes dysregulated in both macular and extramacular RPE-choroid of early-stage AMD patients.
| GO id | Description | q-value |
|---|---|---|
| GO:0016056 | rhodopsin mediated signaling pathway | 2.8E-28 |
| GO:0007603 | phototransduction, visible light | 6.5E-27 |
| GO:0022400 | regulation of rhodopsin mediated signaling pathway | 1.3E-26 |
| GO:0009584 | detection of visible light | 2.0E-26 |
| GO:0007602 | phototransduction | 3.3E-26 |
| GO:0009583 | detection of light stimulus | 8.9E-26 |
| GO:0009581 | detection of external stimulus | 2.1E-24 |
| GO:0009582 | detection of abiotic stimulus | 3.9E-24 |
| GO:0071482 | cellular response to light stimulus | 2.6E-22 |
| GO:0051606 | detection of stimulus | 3.6E-21 |
| GO:0097381 | photoreceptor disc membrane | 8.5E-21 |
| GO:0071478 | cellular response to radiation | 2.6E-19 |
| GO:0009416 | response to light stimulus | 3.5E-19 |
| GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway | 5.8E-18 |
| GO:0071214 | cellular response to abiotic stimulus | 3.2E-17 |
| GO:0009314 | response to radiation | 1.3E-16 |
| GO:0060170 | ciliary membrane | 7.8E-16 |
| GO:0001750 | photoreceptor outer segment | 1.1E-15 |
| GO:0098590 | plasma membrane region | 2.8E-13 |
| GO:0031513 | nonmotile primary cilium | 6.6E-12 |
| GO:0031253 | cell projection membrane | 8.8E-12 |
| GO:0072372 | primary cilium | 1.5E-10 |
| GO:0097458 | neuron part | 5.0E-10 |