Fig 1. Summary of processing stream for T₁ weighted morphometry, HARDI white matter tractography, and rsfcMRI functional connectivity analyses.

Following standard preprocessing, gray and white matter were divided into anatomically-derived parcellations (Desikan atlas). Surface based morphometry (SBM) was used to analyze cortical thickness and volume as well as the volume of subcortical gray matter and white matter regions. Following preprocessing of HARDI data, the orientation distribution function (ODF) for each voxel was calculated. The gray and white matter segmentations from the Desikan atlas were transformed into HARDI space and used as seeds for ROI to ROI tractography. Resting state connectivity data were preprocessed and ROIs from the Desikan atlas were transformed into rsfcMRI space for each subject and used as seeds for ROI to ROI analysis. For both HARDI and rsfcMRI data, connectivity matrices for each subject were created from which group average matrices were made.