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. 2016 Dec 21;42(7):1511–1521. doi: 10.1038/npp.2016.264

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Chemogenetic inhibition of VTA 5-HT_2CR neurons does not alter food intake or operant responding for food reward. (a) Representative image of Cre-dependent expression of hM4D(Gi)-mCherry specifically within the VTA of a 5-HT_2CR^CRE:YFP mouse. (b) Firing rate of 5-HT_2CR^CRE:YPF::hM4D_i-mCherry^VTA neurons decreased upon 10 μM CNO application. (c) CNO 2 mg/kg had no effect on 1 h chow intake (n=14). (d) CNO 2 mg/kg had no effect on the breakpoint in the experimental group [AAV-hM4D (G_i)] compared with the control [AAV-mCherry] in ad libitum condition (n=29) or (e) food-restricted condition (n=30).