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. 2017 Mar 22;12(3):e0173865. doi: 10.1371/journal.pone.0173865

Table 3. Inflammatory factors associated to OCT and UWFA findings of DME.

OCT and UWFA finding p-value
DRT (n = 22) no DRT (n = 36)
IL-6 (ρg/ml) 6.57 (17.60) 1.09 (0.69) 0.044
0.9 [0.9; 1.76] 0.9 [0.9; 0.9]
0.9 to 81.14 0.9 to 4.53
CME (n = 38) no CME (n = 20)
IL-10 (ρg/ml) 1.29 (1.17) 2.28 (3.33) 0.012
1.1 [1.1; 1.1] 1.1 [1.1; 1.32]
1.1 to 8.21 1.1 to 12.12
enlarged FAZ (n = 6) physiological FAZ (n = 36)
IL-8 (ρg/ml) 30.17 (38.69) 9.64 (6.18) 0.031
15.49 [10.73; 25.10] 9.05 [5.02; 12.01]
6.17 to 108.03 0.82 to 30.33
VEGF (ρg/ml) 794.54 (1227.54) 158.55 (239.81) 0.031
374.07 [152.32; 571.07] 26.3 [26.3; 211.52]
26.3 to 3269.42 26.3 to 925.66

Variables are described (above to lower) by mean and standard deviation, median and interquartilic range [percentiles 25th, 75th], and absolute range.

Abbreviations: CME, cystoid macular edema; DRT, diffuse retinal thickening; DME, diabetic macular edema; FAZ, foveal avascular zone; n, number of cases; OCT, optical coherence tomography; UWFA, ultra-widefield fluorescein angiography.