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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Immunol Rev. 2017 Jan;275(1):129–144. doi: 10.1111/imr.12513

Figure 5. Large Insertions and Deletions in HIV-1 BNAbs Mediate Glycan Interactions.

Figure 5

Most large insertions and deletions observed in the structures of HIV-1 BNAbs are involved in mediating glycan interactions. Many of the large deletions that have been observed in crystal structures contribute to maturation by providing steric clearance to nearby glycans such as with A) VRC01 in which a 2 aa deletion in CDR L1 from GL (cyan) to matured VRC01 (red) allows for accommodation of the N276 glycan (yellow sticks). B) Large insertions tend to be employed for penetrating between glycans such as in the maturation of PGT128 where a 6 aa insertion (magenta) in the CDR H2 (red) allowed for the loop to extend between the N301 and N332 glycans (yellow sticks). In both panels, the Env trimer is shown in surface representation with gp120 in green shades and gp41 in orange shades. Glycans are shown as sticks. Antibody heavy chains are colored blue and light chains colored gray.