Table 1.
Inferred Ancestral Antibodies with Structures Determined by X-ray Crystallography
| Antibody | Antigen | Ancestor Typea | PDB Code | Ref |
|---|---|---|---|---|
| PGT121.GL | Unliganded | GL | 4FQQ | (60) |
| NIH45–46.GL | 93TH057 gp120 | GL | 4JDT | (98) |
| NIH45–46.GL | Unliganded | GL | 4JDV | (98) |
| VRC01 GL | gp120 eOD-GT6 | GL | 4JPK | (99) |
| VRC01 GL | Unliganded | GL | 4JPI | (99) |
| PGT121 | Unliganded | GL | 4NPY | (85) |
| VRC26.UCA | Unliganded | GL | 4ODH | (21) |
| CH103 UCA | Unliganded | UCA | 4QHK | (31) |
| CH103 I3.1 | Unliganded | INT | 4QHM | (31) |
| CH103 I2 | Unliganded | INT | 4QHN | (31) |
| CH103 I3.2 | Unliganded | INT | 4QHL | (31) |
| CH59.UA | Unliganded | UCA | 4QF1 | (47) |
| CH58.UA | Unliganded | UCA | 4RIR | (35) |
| CH58.UA | V2 peptide | UCA | 4RIS | (35) |
| PGT121 3H+109L | BG505 SOSIP Trimer | INT | 5CEZ | (58) |
| PGT121 9H+3L | Unliganded | INT | 5CEY | (58) |
| PGT121 32H+109L | Unliganded | INT | 5CEX | (58) |
| NIH45–46.GL | gp120 426c.TM4dV1-3 | GL | 5IGX | (46) |
| 3BNC60.GL | Unliganded | GL | 5F7E | (46) |
| 3BNC60.GL | gp120 426c.TM4dV1-3 | GL | 5FEC | (46) |
| 10E8 gHV-gLV | Unliganded | GL | 5JO5 | (100) |
| VRC03 gHVgLV | Unliganded | GL | 5JOF | (48) |
a
Unmutated Common Ancestor (UCA) defined as containing an inferred unmutated CDR3; Germline Reverted (GL) defined as containing a mature (mutated) CDR3; Ancestral Intermediate (INT)