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. 2017 Apr 1;8(2):228–239. doi: 10.14336/AD.2016.0910

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Copyright: © 2017 Liu, et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — The high viability of DNA pol γ in mitochondria overexpressing wtp53 and d4T attenuates the activity of mtDNA pol γ. (A) wtp53, Δ40p53 and Δ133p53 protein expressions under various conditions, detected by Western blotting. (B) The activity of mtDNA pol γ in mitochondria isolated from the cells with various p53 isoforms. (C). Efficacy of p53 and its isoforms on the activity of DNA pol γ in the presence and absence of d4T. Data represent the average of three independent experiments + SD, *P<0.05.