Fig 3.

A. Forest plot of ICU LOS in patients with AKI regarding early versus late initiating of RRT. B. Sensitivity analysis of secondary outcome of ICU LOS. C. TSA on ICU LOS in patients with AKI receiving early versus late initiating of RRT, which showed that the cumulative Z-curve crossed the conventional boundary for benefit but did not cross the trial sequential monitoring boundary for benefit. Therefore, it established insufficient and inconclusive evidence. The estimated required information size of 6596 patients was calculated using α = 0.05 (two-sided) and β = 0.20 (power 80%), an anticipated estimated mean difference reduction of −1.4, and a heterogeneity correction of 92% in the late RRT group.