Table 2. Summary of post infection detection of HEV RNA, seroconversion and aminotransferaases peaks in G1, G2, and G3 cynomolgus monkeys.
| HEV RNA detection dpi* | Anti-HEV seroconversion dpi* | Aminotransferases peaks** dpi* (corresponding values in IU/L) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Monkey ID | Group | Serum | Faeces | Liver | IgA | IgM | IgG | ALT | AST |
| AD4 | 1 | 7–28 | 7–28 | 14–69 | 28 | 28 | 28 | 21, 28 (125, 173) | 21 (127) |
| AE3 | 7–21 | 7–42 | 14 | 57 | 28 | 28 | - | - | |
| V12 | 14–21 | 7–28 | 14 | 57 | 28 | 28 | 21 (67) | 21; 99 (97; 96) | |
| AC11 | 14–21; 56 | 7–21 | 14 | 28 | 28 | 28 | - | - | |
| AE6 | 2 | 7–160 | 7–160 | 14–160 | 141 | 99 | 57 | 42; 56; 160 (82; 89; 84) | 21 (93) |
| AB19 | 14–160 | 7–160 | 14–160 | 57 | 14 | 57 | 141; 160 (76; 120) | 7; 14; 21; 42; 99 (106; 76; 84; 88; 95) | |
| AD8 | 14–42 | 7–42 | 14–42 | 57 | 28 | 28 | - | - | |
| AC7 | 14–160 | 7–160 | 14–160 | 99 | 14 | 57 | 28; 42; 56; 99; 141; 160 (69; 122; 145; 71; 149; 90) | 21; 42; 56; 69 (107; 74; 125; 80) | |
| AB17 | 3 | --- | --- | --- | --- | --- | --- | --- | --- |
| AD7 | --- | --- | --- | --- | --- | --- | --- | --- | |
| Z2 | --- | --- | --- | --- | --- | --- | --- | --- | |
| AE2 | --- | --- | --- | --- | --- | --- | --- | --- | |
* dpi: days post inoculation
** Aminotransferases peaks: ALT/AST serum levels exceeding at least twice the individual baseline levels.