Fig 6. The CipR and kdsD::ltrB_L1 mutant strains of F. tularensis were attenuated in BALB/c mice by intranasal and intradermal challenge.

Groups of BALB/c mice (n = 10) were challenged and survival monitored following infection by intranasal or intradermal injections using the wild-type Schu S4 strain, CipR mutant, kdsD::ltrB_L1 mutant, and the complemented kdsD mutant strain, as indicated. The calculated LD₅₀ values from these experiments are included in Table 6.