Fig 9. The CipR and kdsD::ltrB_L1 mutant strains of F. tularensis are attenuated in BALB/c mice following small particle aerosol challenge.

A control group of mice were exposed to 33 LD₅₀ of the parent Schu S4 strain, and all succumbed or were moribund by Day 5. In contrast, other mice were challenged by aerosol with either the CipR strain (receiving the equivalent of 43 wild-type LD₅₀) or the kdsD::ltrB_L1 mutant (receiving the equivalent of 100 wild-type LD₅₀) and all survived challenge to Day 21.