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. 2017 Mar 22;12(3):e0174137. doi: 10.1371/journal.pone.0174137

Fig 5. Effect of the CYP4A-blocker, DDMS (1 μM), on coronary reactive hyperemia (CRH) in Tie2-CYP2J2 Tr and WT mice.

Fig 5

The CYP4A-blocker, DDMS, enhanced CRH in both Tie2-CYP2J2 Tr and WT mice. Repayment volume (A) and repayment duration (B) were increased by DDMS in both mouse genotypes. Both repayment volume (A) and repayment duration (B) were increased more in untreated Tie2-CYP2J2 Tr compared to untreated WT mice. Similarly, repayment/debt ratio (C) was increased by DDMS in both mouse genotypes, but was significant in WT mice only. Also, repayment/debt ratio was increased more in untreated Tie2-CYP2J2 Tr compared to untreated WT mice. Baseline CF (D) was not different between the two groups. * P < 0.05 versus untreated WT. # P < 0.05 versus untreated Tie2-CYP2J2 Tr mice. n = 8 per group.