Fig 6. LC–MS/MS analysis of 6-keto-PG-F1α, PG-F2α, PG-D2, PG-E2, and TxB2 in WT and Tie2-CYP2J2 Tr mouse heart perfusates at baseline and post-ischemia.
The levels of prostaglandin 6-Keto-PG-F1α (A), PG-D2 and (C), and thromboxane (Tx)-B2 (E) were not significantly changed due to ischemia or between Tie2-CYP2J2 Tr and WT mice (P > 0.05). In both Tie2-CYP2J2 Tr and WT mice, PG-F2α (B) and PG-E2 and (D) were decreased post-ischemia (P < 0.05). * P < 0.05 versus baseline WT. Ф P < 0.05 versus baseline Tie2-CYP2J2 Tr. n = 8 per group.