Fig 10. A schematic diagram comparing the oxylipin changes observed in response to both brief ischemia and CYP 2J2 over-expression as well as oxylipins’ possible effect on coronary reactive hyperemia (CRH) in WT and Tie2-CYP2J2 Tr mice.
Both ischemia and CYP 2J2 over-expression caused changes in the measured oxylipin profiles. However, the changes associated with ischemia were common to both mouse strains (WT and Tie2-CYP2J2 Tr). Overall, CRH was enhanced in Tie2-CYP2J2 Tr compared to WT possibly through increased EETs, increased EpOMEs, and decreased 8-iso-PGF2α. Grey block arrows indicate the effects of ischemia, whereas black block arrows indicate the effects of ischemia CYP 2J2 over-expression.