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. 2017 Mar 22;12(3):e0174430. doi: 10.1371/journal.pone.0174430

Table 5. Hospital mortality in patients with AG ≤12 or >12 mmol/L and with various serum Cl concentrations.

Outcome Admission serum chloride level (mmol/L)
<95 95–100 100–105 105–108 108–113 113–118 >118
AG ≤12 (n = 63,630)
Hospital mortality 80 (3.7) 139 (1.9) 238 (0.9) 122 (0.8) 119 (1.4) 40 (2.9) 18 (8.1)
- Model 1: unadjusted 4.96 (3.71–6.58) 2.50 (1.96–3.20) 1.13 (0.91–1.40) 1 (ref) 1.79 (1.39–2.31) 3.88 (2.67–5.52) 11.47
(6.65–18.70)
- Model 2# 2.87 (2.13–3.85) 1.59 (1.24–2.05) 1.06 (0.85–1.33) 1 (ref) 1.55 (1.20–2.00) 2.96 (2.02–4.24) 6.76
(3.81–11.39)
- Model 3: Model 2 and Na 1.90 (1.30–2.76) 1.32 (1.002–1.73) 0.99 (0.79–1.25) 1 (ref) 1.62 (1.25–2.09) 3.29 (2.24–4.74) 8.28
(4.62–14.09)
AG >12 (n = 13,089)
Hospital mortality 47 (4.0) 87 (3.0) 117 (2.0) 42 (2.0) 45 (5.0) 13 (11.8) 6 (22.2)
- Model 1: unadjusted 2.01 (1.32–3.08) 1.51 (1.05–2.21) 0.98 (0.69–1.42) 1 (ref) 2.55 (1.66–3.93) 6.51 (3.26–12.21) 13.87
(4.89–34.29)
- Model 2# 1.58 (1.02–2.45) 1.30 (0.89–1.92) 1.01 (0.71–1.46) 1 (ref) 2.11 (1.36–3.27) 4.14 (1.99–8.13) 5.87
(1.91–16.20)
- Model 3: Model 2 and Na 0.92 (0.54–1.56) 0.99 (0.66–1.50) 0.91 (0.63–1.32) 1 (ref) 2.30 (1.48–3.58) 5.45 (2.59–10.84) 11.54
(3.59–33.62)

#model 2: Adjusted for age, sex, Charlson comorbidities score, eGFR and principal diagnosis.