Table 8. Hospital mortality in subgroups of patients with various serum Cl levels.
| Outcome (n = 55,523) | Change in serum chloride within the first 48 hours of hospital admission (mmol/L) | |||||
|---|---|---|---|---|---|---|
| < -4 | -4 to -2 | -2 to 0 | 0 to 2 | 2 to 4 | >4 | |
| Serum Cl <105 mmol/L (n = 33,515) | ||||||
| Hospital Mortality | 13 (1.3) | 30 (1.2) | 88 (1.5) | 120 (1.4) | 133 (1.8) | 237 (2.8) |
| Unadjusted OR (95%CI) | 0.85 (0.45–1.47) | 0.84 (0.54–1.25) | 1 (ref) | 0.98 (0.75–1.30) | 1.25 (0.95–1.64) | 1.96 (1.54–2.53) |
| #Adjusted OR (95%CI) | 0.87 (0.46–1.52) | 0.86 (0.56–1.30) | 1 (ref) | 1.00 (0.76–1.33) | 1.24 (0.94–1.64) | 1.84 (1.43–2.39) |
| Serum Cl 105–108 mmol/L (n = 12,447) | ||||||
| Hospital Mortality | 8 (0.7) | 15 (0.7) | 29 (0.8) | 19 (0.6) | 26 (1.6) | 37 (4.4) |
| Unadjusted OR (95%CI) | 0.89 (0.38–1.85) | 0.83 (0.43–1.53) | 1 (ref) | 0.74 (0.41–1.32) | 2.03 (1.19–3.46) | 5.59 (3.42–9.20) |
| #Adjusted OR (95%CI) | 0.95 (0.40–1.99) | 0.82 (0.43–1.51) | 1 (ref) | 0.69 (0.38–1.23) | 1.80 (1.04–3.10) | 4.35 (2.61–7.31) |
| Serum Cl >108 mmol/L (n = 9,561) | ||||||
| Hospital Mortality | 47 (1.6) | 33 (1.6) | 38 (1.8) | 39 (3.0) | 20 (3.1) | 31 (9.8) |
| Unadjusted OR (95%CI) | 0.90 (0.58–1.39) | 0.89 (0.55–1.42) | 1 (ref) | 1.72 (1.10–2.72) | 1.77 (1.01–3.04) | 6.07 (3.70–9.89) |
| #Adjusted OR (95%CI) | 1.11 (0.72–1.75) | 0.96 (0.59–1.55) | 1 (ref) | 1.61 (1.01–2.56) | 1.51 (0.84–2.63) | 4.33 (2.55–7.31) |
# Adjusted for age, sex, Charlson comorbidities score, eGFR and principal diagnosis.