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. 2017 Mar 8;13(3):e1006658. doi: 10.1371/journal.pgen.1006658

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© 2017 Shadle et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — (A) Fluorescence microscopy using the J2 antibody to detect dsRNA in RD-DUX4i cells treated with doxycyline for 16 hours or transfected with poly(I:C). Note that not all nuclei showed dsRNA aggregation, likely due to asynchronous activation of the DUX4 transgene. (B) Western blot of phosphorylated and unphosphorylated PKR in extracts from RD-DUX4i cells treated with doxycyline for 21 hours or transfected with poly(I:C). (C) Western blot in extracts from RD-DUX4i cells treated with doxycyline for the indicated times and using the indicated antibodies.