Fig. 3.

Parafoveal photoreceptor imaging in remaining subjects. A–C. B-scan OCT, (D–F), confocal AOSLO imaging, and (G–I), split-detector AOSLO. The earliest lesion of this cohort, from KS_0600, manifests as scattered loss of waveguiding in the confocal image. The split-detector image shows a complete and normally dense mosaic of photoreceptors. The B-scan from subject KS_0589 reveals a large late vitelliruptive lesion with significant subretinal debris. The confocal AOSLO image reveals scattered waveguiding photoreceptors, with a cluster of small reflective dots on top of the large debris (E). The split-detector image reveals abnormal photoreceptor morphology and widely varying photoreceptor size over this small area. The bottom left corner of the image contains enlarged photoreceptors with local clearings. With this modality, it does not appear that the debris is covered by photoreceptors as the confocal image suggests. Despite the obvious retinal atrophy and little ellipsoid zone reflectivity in subject KS_0599, the split-detector AOSLO image reveals a near-complete mosaic of photoreceptors at the fovea. The confocal AOSLO image fails to identify many of the photoreceptors, likely due to their abnormal waveguiding. Scale bars 100 μm.