Figure 2. Network analysis of intra-renal interferon pathways in lupus nephritis.
Network analysis was done to determine the extent of interferon pathway activation in lupus nephritis kidneys at flare and after treatment. In flares that ended in complete response, the interferon-α, β and γ pathways were predicted to be upregulated (A). After treatment, only the interferon-β pathway remained upregulated (B). In flares that ended in non-response, the interferon-α and β pathways were predicted to be upregulated (C). After treatment, the interferon-α, β and γ pathways were all predicted to be upregulated (D).