Table 3.

Differentially Expressed Transcripts at Flare and After Treatment in Complete Responders

Transcripts Differentially-Expressed Compared to Normal Kidney at Biopsy 1			Change in Transcript Expression from Biopsy 1 to Biopsy 2		Transcripts that Become Differentially- Expressed Compared to Control After Treatment at Biopsy 2
Gene	Fold Change1	P2	Percent Change3	P4	Gene	Fold Change1	P2
MX1	6.96	0.0000	−47%	0.1475	TGFBI	2.57	0.001
STAT1	4.03	0.0000	−22%	0.3158	FN1	2.23	0.007
HLA-DRB1	3.91	0.003	−6%	0.8138	LCK	2.19	0.005
BST2	3.89	0.0000	−34%	0.0694	ENTPD1	2.11	0.008
IFITM1	3.71	0.001	−20%	0.5124	CX3CR1	2.09	0.002
HLA-C	3.00	0.0004	−19%	0.2562	NFKBIA	0.49	0.0001
C1QB	2.60	0.002	−29%	0.1041	IL8	0.48	0.004
FCER1G	2.58	0.003	−26%	0.1990	IL6R	0.48	0.0003
HLA-A	2.50	0.0007	−27%	0.1276	NFKBIZ	0.47	0.008
IRF7	2.43	0.003	−31%	0.1855	TAL1	0.42	0.0002
CYBB	2.37	0.0007	18%	0.4603	SOCS3	0.31	0.004
ITGAL	2.35	0.006	−1%	0.9793	MME	0.28	0.002
LILRB1	2.09	0.008	−19%	0.43	FKBP5	0.11	0.0000
TNF	2.05	0.001	−10%	0.66
NFATC1	0.48	0.002	25%	0.27
SELE	0.47	0.003	33%	0.27
CEBPB	0.44	0.0005	−35%	0.04
NFIL3	0.44	0.009	−5%	0.87
RORC	0.43	0.002	12%	0.63
CDKN1A	0.32	0.0000	−25%	0.13
CR2	0.10	0.0000	28%	0.50

¹Transcript expression in LN compared to normal controls

²LN versus normal; p≤0.01 and fold change compared to normal >2 or <0.5 to be considered differentially expressed

³Transcript expression from biopsy 1 to biopsy 2

⁴Biopsy 1 versus biopsy 2