Table 4.

Differentially Expressed Transcripts at Flare and After Treatment in Non-Responders

Transcripts Differentially-Expressed Compared to Normal Kidney at Biopsy 1			Change in Transcript Expression from Biopsy 1 to Biopsy 2		Transcripts that Become Differentially-Expressed Compared to Normal After Treatment at Biopsy 2
Gene	Fold Change1	P2	Percent Change3	P4	Gene	Fold Change1	P2
C1QB	4.52	0.0000	−38%	0.04	CFD	8.01	0.0002
MX1	3.90	0.004	67%	0.29	CCL19	5.94	0.0006
ITGAL	3.73	0.0001	66%	0.09	C3	4.96	0.001
ITGB2	3.48	0.0000	25%	0.39	SELL	4.22	0.003
CYBB	3.41	0.0000	59%	0.07	CX3CR1	3.74	0.0000
FCER1G	3.41	0.0004	33%	0.27	CASP1	3.24	0.0000
FCGR3A	3.35	0.006	35%	0.48	IFITM1	3.09	0.006
STAT1	3.09	0.0008	39%	0.25	ITGAX	3.08	0.0007
C1S	3.00	0.0000	10%	0.60	B2M	2.87	0.009
BST2	2.88	0.0000	8%	0.75	CD40	2.87	0.009
C1R	2.79	0.001	−5%	0.85	LCK	2.82	0.0005
FN1	2.75	0.001	−25%	0.36	LCP2	2.77	0.0001
LAIR1	2.68	0.0000	−5%	0.78	C2	2.77	0.008
TGFBI	2.62	0.002	17%	0.59	SLAMF7	2.76	0.008
KIR2DL3	2.51	0.009	−50%	0.04	IL1RN	2.73	0.001
GZMA	2.48	0.002	24%	0.34	IRF8	2.72	0.005
HLA-B	2.44	0.0001	29%	0.27	TAGAP	2.66	0.009
HLA-DRB3	2.44	0.002	37%	0.28	IFI16	2.66	0.0000
LILRA3	2.39	0.001	21%	0.46	JAK3	2.61	0.01
IRF7	2.23	0.009	34%	0.36	FCGR2B	2.61	0.003
HLA-A	2.23	0.004	3%	0.90	CD5	2.55	0.009
BTK	2.20		−1%	0.10	PTPN6	2.42
		0.001					0.0001
PTPRC	2.20	0.01	115%	0.01	ZAP70	2.34	0.006
CSF2RB	2.19	0.002	85%	0.01	NCF4	2.34	0.0009
TNF	2.18	0.0009	48%	0.15	TGFB1	2.34	0.0002
CD6	2.05	0.005	−10%	0.64	ITGAM	2.27	0.0007
MR1	0.50	0.001	10%	0.68	GZMB	2.26	0.003
NOS2	0.49	0.008	45%	0.10	ARHGDIB	2.26	0.0000
CEBPB	0.48	0.002	13%	0.58	CD24	2.25	0.002
ITGA6	0.46	0.0006	−13%	0.51	TLR1	2.21	0.0000
IGF2R	0.45	0.006	−9%	0.74	IKZF1	2.19	0.008
IL6R	0.44	0.0001	4%	0.88	LILRB1	2.18	0.007
C9	0.43	0.0007	−8%	0.71	PRF1	2.15	0.003
ICOSLG	0.43	0.0001	−35%	0.03	CXCL13	2.11	0.008
TFRC	0.42	0.0002	−23%	0.21	CD97	2.11	0.001
CR1	0.42	0.002	33%	0.32	STAT2	2.07	0.0000
BST1	0.41	0.001	32%	0.29	NFATC1	0.50	0.004
SELE	0.40	0.0008	15%	0.61	LTB4R2	0.50	0.003
CISH	0.38	0.0000	−6%	0.73	MAPKAPK2	0.49	0.001
CDKN1 A	0.30	0.0000	−3%	0.90	GPI	0.49	0.001
RORC	0.22	0.0000	−6%	0.81	IL8	0.47	0.004
DPP4	0.22	0.003	−17%	0.67	PDGFB	0.46	0.003
NFIL3	0.21	0.0000	4%	0.90	TRAF4	0.46	0.002
MME	0.15	0.0000	−5%	0.88	CTNNB1	0.45	0.0002
CR2	0.12	0.0000	76%	0.17	CRADD	0.45	0.0006
					TAL1	0.45	0.001
					CD8B	0.44	0.003
					NFKBIA	0.44	0.0000
					TOLLIP	0.40	0.001
					CTSC	0.40	0.0002
					CD274	0.40	0.009
					C5	0.38	0.0000
					KIT	0.37	0.002
					IL12RB1	0.35	0.008
					BLNK	0.35	0.0003
					C6	0.35	0.0000
					CD81	0.34	0.008
					C1QBP	0.34	0.003
					CEACAM6	0.33	0.005
					CFI	0.29	0.0001
					CX3CL1	0.28	0.0001
					VTN	0.25	0.0001
					ABCB1	0.25	0.0005
					DEFB1	0.23	0.002
					SPP1	0.17	0.001
					FKBP5	0.14	0.0004

¹Transcript expression in LN compared to normal controls

²LN versus normal; p≤0.01 and fold change compared to normal >2 or <0.5 to be considered differentially expressed

³Transcript expression from biopsy 1 to biopsy 2

⁴Biopsy 1 versus biopsy 2