Table II.
Change in body composition during therapy
| Measure of Body Compositiona | At Diagnosis (mean±SE) | End of Induction (mean±SE) | End of Delayed Intensification (mean±SE) | pb | |
|---|---|---|---|---|---|
| Body Mass Index Percentile (BMI%) | 70.5±5.5 | 61.6±5.2 | 62.8.±5.2 | <0.001 | |
|
| |||||
| Fat Mass | (%) | 28.6±1.3 | 33.9±1.3 | 37.1±1.3 | <0.001 |
| (kg) | 19.4±1.7 | 20.9±1.7 | 24.1±1.7 | <0.001 | |
|
| |||||
| Lean Mass | (%) | 68.1±1.3 | 62.7±1.2 | 59.8±1.3 | <0.001 |
| (kg) | 41.6±1.6 | 35.6±1.6 | 36.4±1.6 | <0.001 | |
|
| |||||
| Bone Mass | (%) | 3.28±0.094 | 3.43±0.091 | 3.10±0.092 | <0.001 |
| (kg) | 1.99±0.080 | 1.94±0.080 | 1.86±0.080 | <0.001 | |
a
Body mass index percentile calculated from weight and height at time of visit according to CDC age- and sex- norms. Other parameters directly assessed via dual-energy X-ray absorptiometry.
b
p-value for percentages calculated from mixed-effect analysis of variance across time-points (see methods for additional detail).