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. Author manuscript; available in PMC: 2017 Apr 7.
Published in final edited form as: Genet Med. 2016 Sep 22;19(4):421–429. doi: 10.1038/gim.2016.120

Table 2.

Pharmacogenomics clinical decision support interventions implemented in the electronic health record.

Pharmacogenomics clinical decision support interventions Number of
months in
production
Monthly
ratesa

Abacavir - HLA-B*57:01
  Drug Order Attempted, Total Popup Alerts 3.7
    Drug order attempted, alerted patient has positive HLA-B*5701 0.9
    Drug order attempted, alerted patient should be tested for HLA-B*5701 30 2.8
  Patient Tested, Result Positive, Physician Notified, Allergy Added 0.3

Carbamazepine - HLA-B*15:02
  Drug Order Attempted, Total Popup Alerts 1.3
    Drug order attempted, alerted patient has positive HLA-B*1502 27 0.1
    Drug order attempted, alerted patient should be tested for HLA-B*1502 1.2
  Patient Tested, Result Positive, Physician Notified, Problem Added 0.0

Thiopurine - TPMT
  Drug Order Attempted, Total Popup Alerts 77.6
    Drug order attempted, alerted patient has intermediate or low TPMT test results 25 11.4
    Drug order attempted, alerted to consider patient be tested for TPMT 66.2
  Patient Tested, Result Positive, Physician Notified, Problem Added 54.7

Codeine/Tramadol/Tamoxifen - CYP2D6
  Drug Order Attempted, Total PopUp Alerts 15.0
    Drug order attempted, alerted patient at risk with Extensive to Ultra Rapid test result 6.0
    Drug order attempted, alerted patient at risk with Ultra Rapid test result 21 3.9
    Drug order attempted, alerted patient at risk with Poor to Intermediate test result 1.5
    Drug order attempted, alerted patient at risk with Poor test result 3.6
    Drug order attempted, alerted patient at risk with Intermediate to Ultra Rapid test result 0.0
  Patient Tested, Result At RISK, Physician Notified, Problem Added 25.1

Simvastatin - SLCO1B1
  Drug Order Attempted, Total PopUp Alerts 0.7
    Drug order attempted, alerted for TC Genotype 14 0.7
    Drug order attempted, alerted for CC Genotype 0.0
  Patient Tested, Result At RISK, Physician Notified, Problem Added 0.6

Warfarin - CYP2C9/VKORC1
  Drug Order Attempted, Total PopUp Alerts 10 0.7
    Drug order attempted, dosing algorithm recommendations presented for warfarin order 0.7
    Drug order attempted, unable to display dosing algorithm due to missing data 0.0

Clopidogrel - CYP2C19
  Drug Order Attempted, Total PopUp Alerts 5.6
    Drug order attempted, alerted patient at risk with Intermediate test result 4.6
    Drug order attempted, alerted patient at risk with Poor to Intermediate test result 10 0.2
    Drug order attempted, alerted patient at risk with Poor test result 0.8
Patient Tested, Result At RISK, Physician Notified, Problem Added 28.2

Allopurinol - HLA-B*58:01
  Drug Order Attempted, Total PopUp Alerts 4.7
    Drug order attempted, alerted patient at risk with Positive result 6 0.0
    Drug order attempted, alerted patient should be tested for HLA-B*5801 4.7
  Patient Tested, Result At RISK, Physician Notified, Problem Added 0.0
a

Monthly rate of events calculated as same provider, same patient, same drug order within 24 hours.