Table 4.

Technology Platforms and Test Offerings of Four Major NIPS Test Companies

Company	Test Name	Trisomies	Sex Chromosome Aneuploidy	Microdeletions	Technology Platform	Results Reported
Nateraa	Panorama	21, 18, 13	45,X (Turner syndrome), 47,XXY (Klinefelter syndrome), 47,XXX (Triple X syndrome), 47,XYY (XYY syndrome)	22q11.2 (DiGeorge syndrome), 1p36 deletion, 5p (Cri-du chat syndrome), 15q11.2 (Angelman and Prader-Willi syndrome)	SNP analysis via sequencing	High Risk, Low Risk
Illuminab	Verifi	21, 18, 16, 13, 9	45,X (Turner syndrome), 47,XXY (Klinefelter syndrome), 47,XXX (Triple X syndrome), 47,XYY (XYY syndrome)	22q11.2 (DiGeorge syndrome), 1p36, 15q11.2 (Angelman, Prader-Willi syndromes) 5p (Cri-du-chat syndrome), and 4p (Wolf-Hirschhorn syndrome)	Genome-wide sequencing	No Aneuploidy Detected, Aneuploidy Detected, or Aneuploidy Suspected (Borderline Value)
Sequenomc	MaterniT21 Plus	22, 21, 18, 16, 13	45,X (Turner syndrome), 47,XXY (Klinefelter syndrome), 47,XXX (Triple X syndrome), 47,XYY (XYY syndrome)	22q11.2 (DiGeorge syndrome), 1p36 deletion, 5p (Cri-du-chat syndrome), 15q11.2 (Angelman and Prader-Willi syndrome) 4p (Wolf-Hirschhorn syndrome), 8q (Langier-Gideon syndrome), 11q (Jacobsen syndrome)	Genome-wide sequencing	Positive, Negative, Additional Finding
Ariosad	Harmony	21, 18, 13	Yes	No	Targeted sequencing/array	High Risk, Low Risk

^ahttp://www.panoramatest.com/en

^bhttp://www.illumina.com/clinical/reproductive-genetic-health/clinical-labs/nipt.html

^chttps://laboratories.sequenom.com/providers/maternit21-plus/

^dhttp://www.ariosadx.com/