Skip to main content
. Author manuscript; available in PMC: 2017 Mar 22.
Published in final edited form as: J Bone Miner Res. 2015 Sep 11;31(2):358–368. doi: 10.1002/jbmr.2687

Table 1.

Comparison of 33 SNPs (previous conventional study(31)) and 9 phosSNPs (current study) selected in stage 1*

Stage 1 of Zhang et al. (2014)(31) Stage 1 of Current Study
SNP ID Locus Gene Phenotype Analysis P-value SNP ID Locus Gene Phenotype Analysis P-value
rs34920465 1p36.12 ZBTB40 HIP-BMD Combined 3.06×10−9 --- --- --- --- --- ---
rs1430740 1p31.3 MIR1262 LS-BMD Combined 8.46×10−9 --- --- --- --- --- ---
rs11582394 1q32.1 PLEKHA6 FN-BMD Combined 7.14×10−7 --- --- --- --- --- ---
rs11696050 2q34 PTH2R HIP-BMD Combined 3.72×10−8 --- --- --- --- --- ---
rs11130082 3p21.31 FYCO1 LS-BMD Combined 9.73×10−7 --- --- --- --- --- ---
rs6827815 4p16.3 FGFRL1 FN-BMD Combined 6.01×10−7 rs6831280 4p16.3 IDUA FN-BMD Combined 1.21×10−6
rs3755955 4p16.3 IDUA FN-BMD Combined 1.80×10−6
rs17813558 4p16.1 PSAPL1 FN-BMD Combined 9.19×10−7 --- --- --- --- --- ---
rs4974930 4p14 WDR19 HIP-BMD Combined 6.20×10−7 --- --- --- --- --- ---
rs1463104 4q22.1 HSP90AB3P LS-BMD Combined 7.08×10−7 rs1054627 4q22.1 IBSP FN-BMD Female 3.54×10−7
rs4703541 5q13.2 ZNF366 FN-BMD Combined 6.52×10−7 --- --- --- --- --- ---
rs6894139 5q14.3 MEF2C FN-BMD Combined 2.02×10−9 --- --- --- --- --- ---
--- --- --- --- --- --- rs61748601 6p21.2 DNAH8 HIP-BMD Combined 4.83×10−5
rs1871859 6q25.1 C6orf97 LS-BMD Female 5.04×10− --- --- --- --- --- ---
rs28529426 7p22.1 FOXK1 LS-BMD Combined 8.12×10−7 --- --- --- --- --- ---
rs2529750 7p21.1 PRPS1L1 LS-BMD Female 7.04×10−7 --- --- --- --- --- ---
rs10429035 7q21.3 FLJ42280 HIP-BMD Combined 4.24×10−9 --- --- --- --- --- ---
rs13242054 7q22.3 PIK3CG LS-BMD Combined 5.83×10−7 --- --- --- --- --- ---
rs10242100 7q31.31 WNT16 HIP-BMD Combined 4.63×10−8 rs2707466 7q31.31 WNT16 HIP-BMD Combined 1.77×10−6
chr8:78734104 8q21.12 PKIA LS-BMD Combined 1.98×10−7 --- --- --- --- --- ---
rs4424296 8q24.12 TNFRSF11B LS-BMD Combined 5.94×10−10 --- --- --- --- --- ---
rs10868819 9q21.12 KLF9 FN-BMD Combined 6.31×10−7 --- --- --- --- --- ---
chr9:87907046 9q21.33 AGTPBP1 HIP-BMD Male 1.88×10−7 --- --- --- --- --- ---
rs7025969 9q31.3 ACTL7B FN-BMD Female 7.77×10−8 --- --- --- --- --- ---
rs7108738 11p15.1 SOX6 FN-BMD Combined 6.73×10−9 --- --- --- --- --- ---
rs4267051 11p15.1 HPS5 HIP-BMD Female 7.97×10−7
rs525592 11q13.2 LRP5 LS-BMD Combined 9.04×10−7 --- --- --- --- --- ---
rs471753 11q14.2 TMEM135 FN-BMD Combined 2.20×10−7 --- --- --- --- --- ---
--- --- --- --- --- --- rs1318648 12q13.13 ESPL1 FN-BMD Female 9.87×10−5
rs56358776 12q13.13 ESPL1 FN-BMD Combined 5.36×10−5
rs9533095 13q14.11 AKAP11 LS-BMD Female 3.96×10−7 --- --- --- --- --- ---
rs227425 14q24.2 SMOC1 LS-BMD Combined 2.69×10−7 --- --- --- --- --- ---
rs11848357 14q32.11 RPS6KA5 LS-BMD Combined 3.29×10−7 --- --- --- --- --- ---
chr16:86714715 16q24.1 FOXL1 HIP-BMD Female 1.86×10−9 --- --- --- --- --- ---
rs10756 19q12 C19orf2 FN-BMD Combined 7.60×10−7 --- --- --- --- --- ---
--- --- --- --- --- --- rs2287679 19q13.11 GPATCH1 FN-BMD Female 6.59×10−5
rs12481249 20q13.33 OSBPL2 LS-BMD Combined 1.20×10−7 rs310655 20q13.33 SRMS FN-BMD Combined 3.57×10−5
rs170183 21q22.13 CLDN14 HIP-BMD Female 3.71×10−7 --- --- --- --- --- ---
*

Abbreviations: BMD, bone mineral density; FN, femoral neck; HIP, total hip; LS, lumbar spine; phosSNP, phosphorylation-related SNP; SNP, single nucleotide polymorphism. Combined refers to Male and Female. Those SNPs that have attained the conventional genome-wide significance (GWS) (i.e., α = 5.00×10−8) were highlighted in bold font. Shaded regions were matched regions between these two studies, although different SNPs were identified (Note: a region could contain more than one SNP).