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. 2017 Feb 4;8(9):14294–14305. doi: 10.18632/oncotarget.15104

Figure 1. Pravastatin promotes AngII-induced AAA formation in Apoe−/− mice.

Figure 1

Apoe−/− mice were received pravastatin administration (50 mg/kg) in drinking water for 4 weeks followed by AngII infusion (1.44 mg/kg/day) for another 4 weeks. A. Representative images showing macroscopic features of abdominal aortic specimens in mice. B. The incidence and the mortality, and C. the severity of AAA in AngII-infused mice. D. Histological analysis of HE staining, immunohistochemistry of α-actin, and Verhoff-Van Gieson staining in abdominal aortic cross-section. E. Maximal abdominal aortic diameters and F. grades of elastin degradation in aneurysmal tissues. N is 15-23 in each group. Chi-Square test was used for statistical comparisons in B. and C. Unpaired student's t-test was used for statistical comparisons in E and F. *P < 0.05 vs. Vehicle.