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. 2017 Jan 29;8(9):14462–14478. doi: 10.18632/oncotarget.14895

Figure 1. Identification of 5 ribosomal protein genes that are significantly mutated in cancer.

Figure 1

(A) Significantly mutated genes identified due to mutational frequency (MutSig 2.0), mutational clustering (OncodriveCLUST) or accumulation of high functional impact mutations (OncodriveFM). (B) Mapping of mutations affecting the 5 candidate cancer drivers on linear protein diagrams. Non-silent somatic mutations from all 16 cancer types are shown. Protein domains are indicated for each protein. Ribosomal_L18_L5e (pfam00861), Ribosomal_L18_c (pfam14204): RPL5 protein domains. Ribosomal_L5 (pfam00281), Ribosomal_L5_C (pfam00673): RPL11 protein domains. Ribosomal_S7 (pfam00177): RPS5 protein domain. Ribosomal_S10p/S20e (pfam00338): RPS20 protein domain. Ribosomal_S2 (pfam00318): RPSA protein domain.