Figure 4. Degradomic repertoire of KLK6 treated secretome.

(A) Sequence logos generated with WebLogo based on the identified proteolytic events show a preference for cleavage after Arg residues. (B) Schematic diagrams of the cleavage events and respective cleavage sites on protein substrates. Only cleavages found in both experiments with Fc > 1 are shown. DKK1: Dickkopf-related protein 1; VGF: Neurosecretory protein VGF; ADAMTS19: A disintegrin and metalloproteinase with thrombospondin motifs 19; IGFBP4 or 2: Insulin-like growth factor-binding protein 4 or 2; PCD-16: Protocadherin-16; PLTP: Phospholipid transfer protein; HSP7C: Heat shock cognate 71 kDa protein; HSPB1: Heat shock protein beta-1.