Table 2. Methylation status of KvDMR and H19-DMR in SDHD mutant PGLs with and without chromosome 11 LOH.
| Gene mutation and sample ID | 11p15 status | 11q23 status | KvDMR methylation rate | H19-DMR methylation rate | H19-DMR/KvDMR methylation rate. Ratio |
|---|---|---|---|---|---|
| SDHD (10) | LOH | LOH | 0.01 | 0.62 | > 10 |
| SDHD (11) | LOH | LOH | 0.0 | 1.0 | > 10 |
| SDHD (12) | LOH | LOH | 0.01 | 0.96 | >10 |
| SDHD (13) | LOH | LOH | 0.10 | 0.86 | 8.6 |
| SDHD (14) | LOH | n.i | 0.04 | 0.97 | > 10 |
| SDHD (15) | LOH | LOH | 0.07 | 1 | > 10 |
| SDHD (16) | LOH | n.i | 0.02 | 0.75 | >10 |
| SDHD (17) | n.i | LOH | 0.03 | 0.45 | > 10 |
| SDHD (18) | LOH | LOH | 0.02 | 0.96 | > 10 |
| SDHD (19) | LOH | n.i | 0.0 | 0.91 | > 10 |
| SDHD (20) | LOH | LOH | 0.0 | 0.87 | > 10 |
| SDHD (21) | LOH | LOH | 0.08 | 0.76 | > 10 |
| SDHD (22) | LOH | n.i | 0.14 | 0.90 | 6.4 |
| SDHD (23) | No LOH | No LOH | 0.51 | 0.56 | 1 |
| SDHD (24) | LOH | LOH | 0.01 | 0.7 | > 10 |
| SDHD (25) | LOH | LOH | 0.04 | 0.86 | > 10 |
| SDHD (26) | No LOH | No LOH | 0.57 | 0.59 | 1 |
| SDHD (27) | No LOH | No LOH | 0.53 | 0.57 | 1 |
| SDHD (28) | LOH | LOH | 0.17 | 0.66 | 3.9 |
| SDHD (29) | LOH | LOH | 0.15 | 0.68 | 4.4 |
| SDHD (30) | LOH | LOH | 0.21 | 0.70 | 3.3 |
| SDHD (31) | LOH | LOH | 0.16 | 0.68 | 4.4 |
| SDHD (32) | LOH | LOH | 0.12 | 0.71 | 5.9 |
| SDHD (33) | LOH | LOH | 0.13 | 0.65 | 5.2 |
| SDHD (34) | LOH | LOH | 0.11 | 0.70 | 6.4 |
| SDHD (35) | LOH | LOH | 0.13 | 0.69 | 5.4 |
| SDHD (36) | No LOH | No LOH | 0.48 | 0.61 | 1.2 |
LOH: loss of heterozygosity. n.i : not informative.