Table 3. Methylation status of KvDMR and H19-DMR in VHL mutant PCCs with and without chromosome 11 LOH.
Gene mutation and sample ID | 11p15 status | 11q23 status | KvDMR methylation rate | H19-DMR methylation rate | H19-DMR/KvDMR Methylation rate. Ratio |
---|---|---|---|---|---|
VHL (37) | LOH | n.i | 0 | 0.65 | > 10 |
VHL (38) | LOH | LOH | 0.01 | 0.89 | > 10 |
VHL (39) | LOH | LOH | 0.03 | 0.75 | > 10 |
VHL (40) | LOH | LOH | 0.01 | 1 | > 10 |
VHL (41) | LOH | LOH | 0.01 | 1 | > 10 |
VHL (42) | LOH | LOH | 0.01 | 0.83 | > 10 |
VHL (43) | n.i | LOH | 0.01 | failed | - |
VHL (44) | n.i | LOH | 0 | failed | - |
LOH: loss of heterozygosity. n.i : not informative