Table 4. Methylation status of KvDMR and H19-DMR in SDHB mutant tumors with and without chromosome 11 LOH.
| Gene mutation and sample ID | 11p15 status | 11q23 status | KvDMR methylation rate | H19-DMR methylation rate | H19-DMR/KvDMR methylation rate Ratio | Methylation rate of matched blood DNA |
|---|---|---|---|---|---|---|
| SDHB (45) | No LOH | No LOH | 0.39 | 0.45 | 1.1 | KvDMR: 0.39H19: 0.44 |
| SDHB (46) | No LOH | No LOH | 0.68 | 0.60 | 0.9 | |
| SDHB (47) | No LOH | No LOH | 0.48 | 0.31 | 0.6 | |
| SDHB (48) | LOH | No LOH | 0.57 | 0.81 | 1.4 | KvDMR: 0.30H19: 0.51 |
| SDHB (49) | LOH | No LOH | 0.09 | 0.43 | 4.8 | KvDMR: 0.37H19: 0.51 |
| SDHB (50) | LOH | No LOH | 0.33 | 0.91 | 2.8 | |
| SDHB (51) | LOH | LOH | 0.04 | 0.86 | > 10 | |
| SDHB (52) | n.i | No LOH | 0.004 | 0.47 | > 10 | |
| SDHB (53) | No LOH | No LOH | 0.41 | 0.69 | 1.7 | |
| SDHB (54) | No LOH | No LOH | 0.89 | 0.97 | 1.1 | KvDMR: 0.50H19: 0.54 |
| SDHB (55) | No LOH | No LOH | 0.91 | 0.92 | 1.0 | |
| SDHB (56) | No LOH | No LOH | 0.46 | 0.52 | 1.1 | |
| SDHB (57) | No LOH | No LOH | 0.23 | 0.33 | 1.4 |
LOH: loss of heterozygosity. n.i : not informative