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. 2017 Jan 14;8(9):14604–14619. doi: 10.18632/oncotarget.14654

Figure 8. Lenalidomide cooperates with CK1α silencing in inducing apoptosis and cell cycle arrest, modulating β-catenin and AKT survival signalling.

Figure 8

Ki-67 positive H929 cells after transfection with CK1α siRNAs and siGLO green indicator and treated for 3 days with Lena (average of five independent experiments). * indicates p < 0.05. # indicates p < 0.05 between samples treated with Lena alone or in combination of CK1α silencing. Data represent the mean ± SEM of five independent experiments. The right panel shows a representative Contour Plot. Bottom panel: expression of phosphorylated β-catenin on Ser45 (p β-catenin S45), phosphorylated AKT on Ser473 (p AKT S473), total β-catenin and AKT. GAPDH was used as loading control.