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. 2017 Jan 18;8(9):14736–14747. doi: 10.18632/oncotarget.14718

Figure 5. AMPK-autophagy activators attenuate icaritin's cytotoxicity in CRC cells.

Figure 5

HT-29 cells (A–B) or the primary colon cancer cells (two lines, “Patient-1/−2”) (C and D) were pre-treated for 30 min with the AMPK activator Compound 13 (“+C13”, 10 μM) or the autophagy activator MHY1485 (“+MHY”, 10 μM), followed by ICT (10 μM) treatment for 72 hours; Cell viability and cell death were tested by MTT assay (A, C and D) and LDH release assay (B), respectively. Data were expressed as mean ± SD, experiments were repeated five times. n = 5 for each assay. #p < 0.05 vs. “ICT” only group.