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. 2017 Jan 27;8(9):14777–14793. doi: 10.18632/oncotarget.14833

Figure 7. Effects of E2F1 and miR-519d co-transfection on ovarian carcinoma cells.

Figure 7

E2F1 plasmid and miR-519d mimic co-transfection (Mock+Con stands for E2F1-mutant plus miR-519d contorl, E2F1+Con stands for E2F1 plasmid plus miR-519d control ) caused (A) severe growth retardation, (B) promoting G1–S progression, (C) high levels of apoptosis, and reduced (D) migration and (E) invasive ability. E2F1 siRNA and miR-519d inhibitor co-transfection (Mock+Con stands for siE2F1-mutant plus miR-519d inhibitor contorl, siE2F1+Con stands for E2F1 siRNA plus miR-519d inhibitor control ) exhibited (F) slower growth, (G) G1 arrest, (H) increased apoptosis, (I) decreased migration and (J) invasive ability. *p < 0.05. See Supplementary Figure 1.