Table 4. EGFR mutation type in our analysis.

			Xuanwei					Sample type					Sex					Smoking
			Yes		No			Tissue		Plasma			Male		Female			Yes		No
	N	%	N	%	N	%	P	N	%	N	%	P	N	%	N	%	P	N	%	N	%	P
Sensitizing mutations
G719X	11	7.05	6	22.2	5	3.9	0.001	8	11	3	3.8	0.12	6	9.4	5	5.4	0.34	6	9.8	5	5.3	0.276
19-deletion	63	40.4	5	18.5	58	45	0.019	23	31.5	38	47.5	0.04	28	35	35	38	0.58	22	36.1	41	43.2	0.378
L861Q	4	2.6	1	3.7	3	2.3	0.54	3	4.1	1	1.3	0.35	3	4.7	1	1.1	0.306	3	4.9	1	1.1	0.3
L858R	46	29.5	3	11.1	43	33.3	0.038	23	31.5	23	28.8	0.71	16	25	30	32.6	0.305	19	31.1	27	28.4	0.813
G719X, L861Q	1	0.6	0	0	1	0.8	0.10	1	1.4	0	0	0.48	0	0	1	1.1	1.00	0	0	1	1.1	1.00
G719X, L858R	1	0.6	1	3.7	0	0	0.173	1	1.4	0	0	0.48	0	0	1	1.1	1.00	0	0	1	1.1	1.00
19-deletion, L858R	1	0.6	0	0	1	0.8	0.10	0	0	1	1.3	1.00	0	0	1	1.1	1.00	0	0	1	1.1	1.00
Resistance mutations
T790M	3	1.9	0	0	3	2.3	0.10	1	1.4	2	2.5	1.00	0	0	3	3.3	0.269	1	1.6	2	2.1	1.00
S768I	7	4.5	3	11.1	4	3.1	0.10	4	5.5	3	3.8	0.71	5	7.8	2	2.2	0.124	4	6.6	3	3.2	0.433
20-insertion	5	3.2	0	0	5	3.9	0.588	2	2.7	2	2.5	1	3	4.7	2	2.2	0.401	3	4.8	2	2.1	0.38
S768I,T790M	2	1.3	2	7.4	0	0	0.029	0	0	2	2.5	0.5	2	31	0	0	0.167	2	3.3	0	0	0.151
Combination of sensitizing and resistance mutations
19-del, T790M	3	1.9	0	0	3	2.3	1.00	0	0	3	100	0.25	0	0	3	3.3	0.269	0	0	3	3.2	0.281
G719X, S768I	7	4.5	5	18.4	2	1.6	< 0.0001	5	6.8	2	2.5	0.26	1	1.6	6	6.5	0.241	1	1.6	6	6.3	0.248
S768I, L858R	1	0.6	0	0	1	0.8	0.10	1	1.4	0	0	0.48	0	0	1	1.1	1.00	0	0	1	1.1	1.00
L858R, G719X, S768I	1	0.6	1	3.7	0	0	0.17	1	1.4	0	0	0.48	0	0	1	1.1	1.00	0	0	1	1.1	1.00