Table 2. Univariate and multivariate analyses of prognostic factors for disease-free survival or disease-specific survival of stage I-III CRC patients in the study cohort.
Variables | Univariate analysisa | Multivariate analysis | ||||
---|---|---|---|---|---|---|
HR | 95 % CI | P value | HR | 95 % CI | P value | |
Disease-free survival | ||||||
Age (≥ 60/< 60 years) | 1.495 | 1.008–2.216 | 0.045 | 1.350 | 0.907–2.010 | 0.139 |
Sex(male/female) | 1.014 | 0.705–1.460 | 0.939 | |||
Tumor location(rectum/colon) | 1.141 | 0.793–1.642 | 0.478 | |||
Tumor size (≥ 5/< 5 cm) | 1.025 | 0.707–1.487 | 0.895 | |||
Bowel obstruction/perforation (yes/no) | 0.955 | 0.390–2.340 | 0.920 | |||
Differentiation grade (poor/well + moderate) | 1.807 | 1.236–2.643 | 0.002 | 1.402 | 0.949–2.070 | 0.090 |
Local invasion (T3–T4/T1–T2) | 1.074 | 0.675–1.708 | 0.764 | |||
Serum CEA level (≥ 10/ < 10 ng/mL) | 1.002 | 0.695–1.444 | 0.991 | |||
TNM stage (III/I + II) | 2.098 | 1.451–3.034 | < 0.001 | 1.933 | 1.331–2.807 | 0.001 |
PRDX2 expression (high/low) | 2.575 | 1.724–3.845 | < 0.001 | 2.322 | 1.536–3.509 | < 0.001 |
Disease-specific survival | ||||||
Age (≥ 60/< 60 years) | 1.752 | 1.096–2.801 | 0.019 | 1.652 | 1.030–2.649 | 0.037 |
Sex (male/female) | 1.014 | 0.668–1.540 | 0.948 | |||
Tumor location (colon/rectum) | 1.084 | 0.714–1.647 | 0.704 | |||
Tumor size (≥ 5/< 5 cm) | 0.852 | 0.559–1.299 | 0.457 | |||
Bowel obstruction/perforation (yes/no) | 0.978 | 0.359–2.668 | 0.966 | |||
Differentiation grade (poor/well + moderate) | 2.019 | 1.316–3.097 | 0.001 | 1.671 | 1.079–2.589 | 0.022 |
Local invasion (T3–T4/T1–T2) | 1.229 | 0.705–2.142 | 0.468 | |||
Serum CEA level (≥ 10/ < 10 ng/mL) | 1.017 | 0.668–1.547 | 0.939 | |||
TNM stage (III/I + II) | 1.809 | 1.186–2.760 | 0.006 | 1.578 | 1.030–2.417 | 0.036 |
PRDX2 expression (high/low) | 2.388 | 1.502–3.798 | < 0.001 | 2.046 | 1.270–3.296 | 0.003 |
Abbreviations: CEA, carcinoembryonic antigen; CI, confidence interval; HR, hazard ratio; PRDX2, peroxiredoxin 2; TNM, tumor-node-metastasis.
a In univariate analyses, log-rank tests were conducted.
b In the multivariate Cox proportional hazard model, only variables with P < 0.05 in univariate analysis were included and the “enter method” was applied.