Table 3. XAF1 promoter methylation status and IDH1 status in HGG patients.
N | XAF1-M% (N) | N | XAF1-M% (N) | N | XAF1-M% (N) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
All | 80 | 32.5 (26) | Grade III | 26 | 69.2 (18) | Grade IV | 54 | 14.8 (8) | |||||
IDH1wt | 60 | 10.0 (6) | IDH1wt | 8 | 0.0 (0) | IDH1wt | 52 | 11.5 (6) | |||||
IDH1mut | 20 | 100.0 (20) | IDH1mut | 18 | 100.0 (18) | IDH1mut | 2 | 100.0 (2) |
Cases (N) | XAF1-M | XAF1-UM | IDH1mut | IDH1wt | XAF1-MIDH1mut | XAF1-MIDH1wt | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Grade III* (26) | 18 | 8 | 18 | 8 | 18 | 0 | ||||||||
Grade IV* (54) | 8 | 46 | 52 | 2 | 2 | 6 | ||||||||
Grade III (18) IDH1mut | 18 | 0 | 18 | 0 | 18 | 0 | ||||||||
Grade III (8) IDH1mut | 0 | 8 | 0 | 0 | 0 | 8 | ||||||||
Grade IV (2) IDH1mut | 2 | 0 | 2 | 0 | 2 | 0 | ||||||||
Grade IV (58) IDH1mut | 6 | 52 | 0 | 58 | 0 | 6 | ||||||||
Recurrent grade III (6) | 6 | 0 | 6 | 0 | 6 | 0 | ||||||||
Recurrent Grade IV (10) | 2+ | 8 | 2+ | 8 | 2+ | 0 |
*Histological tumor grading. +derived from OA.