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. 2017 Jan 20;8(9):15136–15148. doi: 10.18632/oncotarget.14767

Figure 4. Reproduction of data from the TCGA database with the cBioPortal tool.

Figure 4

The amplifications of candidate genes, ERCC1, ERCC2, CDKN1B and MARK4 correlated with gene expression and were associated with patient outcomes. Kaplan-Meier analysis of OS and PFS was performed with the copy number of the candidate gene as a categorical variable, so that the effects of genes with unaltered and altered copy numbers could be compared. The results of a Cox proportional hazards test, with residual disease as a copredictor, are shown as P values. The correlations between the copy numbers and the mRNA levels of the candidate genes, determined through RNA Seq analysis of the TCGA datasets, are also shown.