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. 2017 Jan 20;8(9):15230–15241. doi: 10.18632/oncotarget.14774

Figure 2. Effects of plumbagin on the mRNA expression of VEGF-A, VEGFR-2, ang2, Tie2, and FLT1 genes in SMMC-7721 cells co-cultured with EA.hy926 cells.

Figure 2

After being exposed to the indicated concentrations of plumbagin (1.25, 2.5, 5 μM), Thalidomide (25 μM) for 24 h, the mRNA expression of ang2 (A) FLT1 (B) VEGF-A (C) VEGFR-2 (D) and Tie2 (E) were analyzed using quantitative real-time PCR. β-actin was used as an internal control. Thalidomide (25 μM) was used as the positive control. The data represent the mean values of three experiments ± SE. *P < 0.05, **P < 0.01, ***p < 0.001 compared to co-culture with the hy926 cells.