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. 2017 Jan 20;8(9):15230–15241. doi: 10.18632/oncotarget.14774

Figure 3. Plumbagin dose-dependently inhibits bFGF, ET-1, and VEGF in vitro.

Figure 3

(A–D) After incubation with plumbagin, the co-cultured cells (SMMC-7721 cells and EA.hy926 cells) were stimulated with various concentrations of plumbagin (1.25, 2.5, 5 μM), Thalidomide (25 μM) for 24 h. Thalidomide (25 μM) was used as the positive control, and the bFGF, CTGF, ET-1, and VEGF cytokines in the culture supernatants were measured using ELISA. The statistical analysis showed that plumbagin suppressed the bFGF, ET-1, and VEGF production in a dose-dependent manner. The data represent the mean values of three experiments ± SE. *P < 0.05, **P < 0.01, ***p < 0.001 compared to co-culture with hy926 cells.