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. 2017 Jan 27;8(9):15283–15293. doi: 10.18632/oncotarget.14843

Figure 6. Low expression of LINC00341 increased tumor metastasis.

Figure 6

(A–B) Meta-analysis estimated the relationship between LINC00341 expression and distant metastasis (A, N = 1373) or lymph node metastasis (B, N = 1726) in breast cancer. Series ID, metastasis (events), total number of samples in groups and combined odds ratio (OR) with 95% confidence region are shown. Data type of dichotomous, Mantel-Haenszel method and fixed effects model were selected to estimation. (C) Pearson correlation analysis the association of mRNA expression between LINC00341 and CD36, ICAM2, PECAM1 in breast cancer tissues, respectively (N = 1101). (D) GSEA enrichment score curves showing the relationship between apical junction pathway and LINC00341 expression. GSEA analysis hallmark apical junction pathway in breast cancer patients of TCGA database (N = 1101). Top: X-axis indicates genes with high expression in the samples with low expression of LINC00341 (left end) and genes with high expression in the samples with high expression of LINC00341 (right end). The green curve indicates the enrichment score (ES). The negative enrichment score in LINC00341 high expression end indicates up-regulation of apical junction pathway in the LINC00341 high expression samples. Middle: the black lines mean genes expression in apical junction pathway. (E) GSEA enrichment score curves showing the relationship between LINC00341 expression and genes with GABP binding motif. (F–G) Gene sets with the FDR q-value less than 0.25 were subjected to leading edge analysis from (D-E). The top 30-ranked genes were shown. Red and blue are represented as high and low expression in the group of LINC00341 low expression, respectively.