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. 2017 Jan 21;8(9):15294–15306. doi: 10.18632/oncotarget.14783

Figure 1. mRNA and miRNA unsupervised hierarchical clustering and pathway analysis with the genes found in the integrative analysis.

Figure 1

(A) The miRNA cluster 3 (blue color) was enriched with cases with lymph node metastasis (LN) and T3-T4 penile tumors. (B) mRNA cluster 3 (blue color) was mainly composed by cases with poor prognosis features: larger tumors (T3 and T4), LN and perineural invasion (PI). Most of the samples were HPV negative (miRNA and mRNA cluster 3 presented one and two HPV positive samples, respectively). (C) miRNA and mRNAs interaction networks in penile carcinomas (NAViGaTOR version 2.3). Circles in blue, red and green represent the mRNA belonging to the main canonical pathway altered in PeCa. Edges indicate the interaction between genes and miRNA according to the pathways (blue, red and green). Interactions among genes from different pathways are represented by non-continue edges. Triangles in the top left indicate the genes with highest number of interactions in PeCa. AR presented the highest number of interactions with other genes (1,182). Growth factor related pathway highlighted genes belonging to EGFR, VEGF and PDGF pathways. PI: Perineural invasion; LN-: absence of lymph node metastasis; LN+: lymph node metastasis confirmed by pathological analysis. T1 to T4: Tumor size.