Table 2. Clinical and histopathological features of PeCa cases (N = 59).
| Variable | Samples used for microarray N (%) | Validation set of samples N (%) |
|---|---|---|
| Number | 23 | 36 |
| Age (years) | ||
| Median (range) | 59.2 (31–91) | 58.6 (30–92) |
| Follow-up (months) | ||
| Median (range) | 15.3 (1.6–60) | 20.3 (1–60) |
| Histological classification | ||
| Usual SCC | 20 (87%) | 33 (91.7%) |
| Mixed* | 1 (4.3%) | 3 (8.3%) |
| Papillary | 2 (8.7%) | 0 (0.0%) |
| Histological grade | ||
| I | 5 (21.7%) | 12 (33.3%) |
| II | 9 (39.2%) | 17 (47.2%) |
| III | 7 (30.4%) | 7 (19.5%) |
| NI | 2 (8.7%) | 0 (0.0%) |
| HPV infection | ||
| HPV-Positive# | 7 (30.4%) | 9 (25%) |
| HPV-Negative | 16 (69.6) | 27 (75%) |
| Lymph node metastasis | ||
| Presence | 9 (39.2%) | 13 (36.1%) |
| Absence | 13 (56.5%) | 21 (58.3%) |
| ND | 1 (4.3%) | 2 (5.6%) |
| Perineural Invasion | ||
| Presence | 5 (21.7%) | 13 (36.1%) |
| Absence | 18 (78.3%) | 23 (63.9%) |
| T Stage | ||
| 1–2 | 14 (60.8%) | 22 (61.1%) |
| 3–4 | 9 (39.2%) | 14 (38.9%) |
Patients were divided in two groups, the same set of samples used in the microarray experiments (N = 23) and a validation set of samples (N = 36).
SCC: squamous cell carcinoma; HPV: human papilloma virus; ND: Not determined. *Mixed tumors comprised: 3 usual - sarcomatoid subtype and one usual - papillary subtypes. NI: Not informed (two papillary carcinomas). #Sixteen cases were HPV positive: seven cases were evaluated by microarrays (6 HPV16 and 1 HPV18) and nine for data validation (8 HPV16 and 1 HPV33).